Translocation t(2;5)(p23;q35) Common to Malignancies With Features of So-Called Malignant Histiocytosis
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چکیده
We report the molecular. cytogenetic. and immunologic characterization of three hematologic malignancies that contained characteristic t(2;5) chromosomal translocations. The clinicopathologic features in all three cases fit the disease spectrum of so-called malignant histiocytosis (MH). All cases expressed activation antigens including Ki-1 (CD 30). but no lineage-restricted pattern of cellular antigen expression was observed. Cell lines SUP-M2 and SU-DHL-1 established from two of the cases showed rearranged I T-cell receptor (IITCR) genes nonproductive of full-length t TCR mRNA and therefore not helpful in unequivocal establishment of lineage derivation. The cornmon cytogenetic feature was a reciprocal translocation between chromosomes 2 and 5, involving bands 2p23 and
منابع مشابه
Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis.
We report the molecular, cytogenetic, and immunologic characterization of three hematologic malignancies that contained characteristic t(2;5) chromosomal translocations. The clinicopathologic features in all three cases fit the disease spectrum of so-called malignant histiocytosis (MH). All cases expressed activation antigens including Ki-1 (CD 30), but no lineage-restricted pattern of cellular...
متن کاملMalignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature.
In this paper, the investigators report a well documented case of malignant histiocytosis (MH) with a t(2;5)(p23;q35) translocation. A breakpoint in 5q35 appears to be specific, either for the disease or for a subclass of the disease. Additional cases of MH with cytogenetics are needed. This will help to determine if one class of MH or several subclasses can be defined by cytogenetic anomaly(ies).
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